MGF 505-7R

Alternative Names:

MGF-505-7R, pMGF505-7R

Essential for Growth?:

Not required in primary macrophages (ASFV-HLJ/18), Reduced growth in primary macrophages (ASFV-CN/GS/2018)

Essential for Virulence?:

Partially (ASFV-HLJ/18), Yes (ASFV-CN/GS/2018)

Description:

Experimentally verified to inhibited proinflammatory IFN-γ-mediated JAK STAT1 signaling by directly interacting with JAK1 and JAK2.